Most research shows that taking aloe by mouth can reduce, An inflammatory condition that causes rash or sores on the skin or mouth (, Obesity. 1996;2(2):271-277. Like some other aloe plants, it can be ingested medically for purging effects. View abstract. View abstract. J Altern Complement Med. Schmidt JM, Greenspoon JS. However, taking aloe does not seem to be linked with a lower risk of getting lung cancer. View abstract. Planta Med 1992;58(suppl 1):A586-A587. Non-randomized open clinical evaluation on the effectiveness of "Mepentol Leche"]. Pecere, T., Sarinella, F., Salata, C., Gatto, B., Bet, A., Dalla, Vecchia F., Diaspro, A., Carli, M., Palumbo, M., and Palu, G. Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin. 2012;65(2):374-378. Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. View abstract. 2011;11(2):142-148. Richardson, J., Smith, J. E., McIntyre, M., Thomas, R., and Pilkington, K. Aloe vera for preventing radiation-induced skin reactions: a systematic literature review. Eshghi F, Hosseinimehr SJ, Rahmani N, et al. Aloe … Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Cochrane.Database.Syst.Rev. Adv Wound Care. Gerodontology. View abstract. 2020;20(1):146. Side Effects of Cape Aloe. View abstract. Lee A, Chui PT, Aun CST, et al. View abstract. But other research suggests that using a salt water spray containing aloe and other ingredients does reduce the severity of sores compared to a control salt water spray. Prevention of acute radiation-induced proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in pelvic cancer patients. Some research also shows that applying aloe cream reduces wound size compared to applying, Diabetes. Skin damage caused by radiation therapy (radiation dermatitis). Dannemann, K., Hecker, W., Haberland, H., Herbst, A., Galler, A., Schafer, T., Brahler, E., Kiess, W., and Kapellen, T. M. Use of complementary and alternative medicine in children with type 1 diabetes mellitus - prevalence, patterns of use, and costs. Wu, J. H., Xu, C., Shan, C. Y., and Tan, R. X. Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var. Also, other research suggests that applying aloe gel does not seem to delay new canker sores. Thamlikitkul V, Bunyapraphatsara N Riewpaiboon W Theerapong S Chantrakul C et al. A type of inflammatory bowel disease (ulcerative colitis). Rhein and aloe-emodin kinetics from senna laxatives in man. Also, it aggravates health conditions such as Crohns disease, ulcerative colitis, hemorrhoids, etc. Alam S, Ali I, Giri KY, Gokkulakrishnan S, Natu SS, Faisal M, Agarwal A, Sharma H. Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis. Dry skin. Effect of a dentifrice containing Aloe vera on plaque and gingivitis control. Cochrane Database Syst Rev. Planta Med 2002;68(11):957-960. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. Acne. Make sure to follow the specific product instructions and take as directed on the label, or consult a licensed healthcare practitioner before use. Phytomedicine 1996;3:241-3. View abstract. Panahi Y, Davoudi SM, Sahebkar A, et al. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Detoxification effects of aloe polysaccharide and propolis on the urinary excretion of metabolites in smokers. Also, eating 30-40 mL of aloe gruel does not improve immune function in people with HIV compared to antiretroviral therapy. Coopoosamy RM, Naidoo KK. Euforia-induced acute hepatitis in a patient with scleroderma. Cape aloe is similar to aloe vera, except that cape aloe leaf has more laxative properties. 2003;69(3):269-271. Investigations of the laxative action of aloin in the human colon. 2008;18:612-4. CMAJ. View abstract. J.Eur.Acad.Dermatol.Venereol. Cosmetic Ingredient Review Expert Panel. 1994;17:651-3. 2005;28(6):482-485. African Cape Aloe … View abstract. Planta Med. View abstract. View abstract. Herbal remedy-associated acute renal failure secondary to Cape aloes. Avoid aloe juice during pregnancy or breast-feeding. Lee, K. H., Kim, J. H., Lim, D. S., and Kim, C. H. Anti-leukaemic and anti-mutagenic effects of di(2-ethylhexyl)phthalate isolated from Aloe vera Linne. Burusapat C, Supawan M, Pruksapong C, Pitiseree A, Suwantemee C. Topical aloe vera gel for accelerated wound healing of split-thickness skin graft donor sites: a double-blind, randomized, controlled trial and systematic review. Alvagel as a therapeutic agent in the treatment of roentgen and radium burns. Acute bullous allergic dermatitis due to local application of aloe leaves. Studies of aloe. Am J Kidney Dis. View abstract. 2013;(577):1-266. Syed, T. A., Ahmadpour, O. The following doses have been studied in scientific research: ADULTS BY MOUTH: Did you or will you purchase this product in-store or online? Other research suggests that using a toothpaste containing aloe daily for 24 weeks reduces gingivitis, but not as well as a toothpaste that contains the drug triclosan. 2005;19:326-31. A case of acute liver damage after aloe vera ingestion has been reported. Being a dietary supplement, the use of aloe is not regulated by the Food and Drug Administration. Low potassium levels can increase the risk of side effects of digoxin (Lanoxin). View abstract. Simao, D. A., Lima, E. D., Souza, R. S., Faria, T. V., and Azevedo, G. F. [Hand-foot syndrome induced by chemotherapy: a case study]. But not all research agrees. Complement Ther Med. BMC Complement Med Ther. Aloe vera extract 0.5% in hydrophilic cream versus aloe vera gel for the measurement of genital herpes in males. What factors influenced or will influence your purchase? There has been one report that using the gel as standard wound therapy delayed healing. This survey is being conducted by the WebMD marketing sciences department. A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention of radiation dermatitis in pediatric patients. de Oliveira SM, Torres TC, Pereira SL, et al. Hogan, D. J. (check all that apply). 2013 May;19(5):425-8. Esua, M. F. and Rauwald, J. W. Novel bioactive maloyl glucans from aloe vera gel: isolation, structure elucidation and in vitro bioassays. View abstract. View abstract. Trop Med Int Health 1996;1:505–9.. View abstract. Akhtar M, Hatwar S. Efficacy of Aloe vera extract cream in management of burn wound. View abstract. Successful treatment of acute radiation proctitis with aloe vera: a preliminary randomized controlled clinical trial. J Okla.Dent.Assoc 2002;92(3):40-43. Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study. View abstract. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. Rabe C, Musch A, Schirmacher P, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. 2007;2:45. Some early research also shows that using a mouth wash containing aloe reduces plaque in adolescents. Early research shows that applying aloe to the skin might help skin survive frostbite injury. Heliyon. Hunter, D. and Frumkin, A. BMC Complement Altern Med 2018;18(1):264. doi: 10.1186/s12906-018-2326-2. View abstract. Rieger, L. and Carson, R. E. The clinical effects of saline and aloe vera rinses on periodontal surgical sites. Lin, J. G., Chen, G. W., Li, T. M., Chouh, S. T., Tan, T. W., and Chung, J. G. Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. View abstract. View abstract. Montaner JS, Gill J, Singer J, et al. G.Ital.Dermatol.Venereol. 2005;88 Suppl 4:S173-6. Phytomedicine 1996;3:245-8. 2-15-1988;138(4):336-338. View abstract. 2012;31:95-103. Endocr.Metab Immune.Disord Drug Targets. 't Hart, L. A., van den Berg, A. J., Kuis, L., van Dijk, H., and Labadie, R. P. An anti-complementary polysaccharide with immunological adjuvant activity from the leaf parenchyma gel of Aloe vera. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L juice. J Infect.Dev Ctries. HIV/AIDS. 2010;105(5):404-405. Oyelami OA, Onayemi A, Oyedeji OA, et al. Clinical efficacy of an Aloe vera gel versus a 0.12% chlorhexidine gel in preventing traumatic ulcers in patients with fixed orthodontic appliances: a double-blind randomized clinical trial. It can also trigger … J Wound Ostomy Continence Nurs 2003;30:68-71. Cutis 1991;47(3):193-196. 1996;12:153-7. Aloe vera extract 0.5% in a hydrophilic cream versus Aloe vera gel for the management of genital herpes in males. View abstract. PLoS Negl Trop Dis. Mansourian A, Momen-Heravi F, Saheb-Jamee M, et al. View abstract. Cascara sagrada, aloe laxatives, O-9 contraceptives are category II-FDA. If you take aloe juice, you may experience some side effects, such as stomach pain and cramping, says the NIH. Heggers, J. P., Kucukcelebi, A., Listengarten, D., Stabenau, J., Ko, F., Broemeling, L. D., Robson, M. C., and Winters, W. D. Beneficial effect of Aloe on wound healing in an excisional wound model. The dose of your diabetes medication might need to be changed. View abstract. J Burn Care Rehabil 1988;9:156-9. López-Jornet P, Camacho-Alonso F, Molino-Pagan D. Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome. Some research shows that using an aloe solution 2-3 times daily during radiation therapy or chemotherapy can make this condition less severe. Efficacy of aloe vera gel in the treatment of vulval lichen planus. View abstract. View abstract. The Tan Sheet May 13, 2002. Savchak VI. "Water pills" can also decrease potassium in the body. View abstract. View abstract. Fitoterapia 2007;78(3):219-222. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Puataweepong P, Dhanachai M, Dangprasert S, et al. Precautions: Long term use of Aloe as a laxative can deplete the body of potassium, and low levels of potassium can cause dangerous irregularities of heart beats. Evaluation of polymannoacetate (carrisyn) in the treatment of AIDS. How Aloe Ferox is effective for various diseases is listed in repertory format. Some early research suggests that applying aloe gel does not improve the healing rate of bedsores compared to using gauze moistened with salt water. Hepatogastroenterology 1990;37(6):601-605. J Med Food 2004;7:61-6. Some laxatives can decrease potassium in the body. Swelling (inflammation) of the liver (hepatitis). ScientificWorldJournal. A formula partially made of aloe is considered an effective laxative, according to MayoClinic.com 2⭐⭐This is a verified and trusted source Goto Source . (check all that apply), What factors are most important to you? View abstract. Ishii Y, Tanizawa H, Takino Y. Fogleman, R. W., Chapdelaine, J. M., Carpenter, R. H., and McAnalley, B. H. Toxicologic evaluation of injectable acemannan in the mouse, rat and dog. View abstract. View abstract. 2011 Feb;23(2):44-8. View abstract. Early research shows that applying a specific product containing acemannan, a chemical from aloe, to the tooth socket after standard treatment reduces pain and improves symptoms from dry socket more than standard treatment alone. Cancer Lett 7-28-2006;239(1):55-63. View abstract. Inhibition of Cl- channels as a possible base of laxative action of certain anthraquinones and anthrones. Luyckx VA, Ballantine R, Claeys M, Cuyckens F, Van den Heuvel H, Cimanga RK, Vlietinck AJ, De Broe ME, Katz IJ. View abstract. Digestion. Common side effects of aloe include: blood sugar (hypoglycemia) Burning and itching of the skin (infrequent) Stomach pain and cramps (high doses) Effects of aloe sterol supplementation on skin elasticity, hydration, and collagen score: a 12-week double-blind, randomized, controlled trial. Syed TA, Cheema KM, and Ahmad SA et al. View abstract. Williams LD, Burdock GA, Shin E, Kim S, Jo TH, Jones KN, Matulka RA. Eur Arch Paediatr Dent. Evaluation of acemannan in providing pain relief in patients with recurrent aphthous stomatitis. Studies of aloe. Medications for diabetes (Antidiabetes drugs) interacts with ALOE. A mild form of gum disease (gingivitis). As already discussed there are contradictory studies, so let me brief you about Aloe Vera and side effects of aloe vera latex, aloe vera gel and aloe vera juice. View abstract. View abstract. Native to Southern Africa, it is colloquially called ‘bitter aloe’ or ‘cape aloe’. J Altern Complement Med 2013;19(5):429-34. 2016;29(6):309-17. View abstract. Clinical trial in new cases of diabetes mellitus. View abstract. BMJ Case Rep 2012;2012. When taken orally aloe latex is a type of laxative called a stimulant laxative. J Ethnopharmacol 1999;68:3-37. View abstract. Angiology 1985;36(8):485-492. J Oral Pathol Med 2012;41(10):755-61. 1998;11:273-6. J Am Podiatr.Med Assoc 1994;84(2):77-81. Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis. Aloe vera extract 0.5% in hydrophilic cream versus aloe vera gel for the measurement of genital herpes in males. 2004 Sep 1;60:171-7. Miller MB, Koltai PJ. J Clin Pharm Ther. Evaluation of the efficacy of two mouthrinses formulated for the relief of xerostomia of diverse origin in adult subjects. Precautions and Adverse Events: Avoid or contact a licensed healthcare practitioner, if you have allergies to plants in the order Asparagales (asparagus, … Nassiff HA, Fajardo F Velez F. Efecto del aloe sobre la hyperlipidemia en pacientes refractarios a la dieta. View abstract. Aliment Pharmacol Ther 2004;19:521-7. Those words truly describe the Cape Aloe Bitter Crystals from The House of Aloes in South Africa. J Nat Prod 1996;59:541-3. West DP, Zhu YF. Lee, H. Z., Lin, C. J., Yang, W. H., Leung, W. C., and Chang, S. P. Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells. A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children. View abstract. I Clinical trial in new cases of diabetes mellitus. 2012;2012:810234. View abstract. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Wang, Z. W., Huang, Z. S., Yang, A. P., Li, C. Y., Huang, H., Lin, X., Liu, Z. C., and Zhu, X. F. [Radioprotective effect of aloe polysaccharides on three non-tumor cell lines]. Effects of low-dose Aloe sterol supplementation on skin moisture, collagen score and objective or subjective symptoms: 12-week, double-blind, randomized controlled trial. View abstract. Vet.Hum.Toxicol 1992;34(2):144-147. Asian Biomedicine 2009;3(4):375-382. World J Gastroenterol. 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